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Chem. : oral, 747 pathogenicity, 558 vaginal flora, 555 Primary metabolites, definition of, 960 Primary producers, 383 Primary vaccine failure, 1068 Primordial germ cell wall (PGCW), 948 Prion diseases: drug development, 8401 history, 837 human hereditary, 838 and immune system, 840 routes of infection, 840 transmissible spongiform encephalopathies, 83740 Prions, 82941 brain damage induction, 839 as copper-binding proteins, 830 definition, 829 GPI anchor, 830, 835 molecular biology: cellular prion protein (PrPC), 830 Prnp gene, 82930 PrP protein, 8301 octarepeats, 830, 838 protease resistancesensitivity, 830 protein only hypothesis, 8316 and mice devoid of PrP, 833 prion strains and species barrier, 8335 proposed conversion methods, 8356 PrP glycosylation, 834, 835 virus and virino hypothesis, 833 yeast prions, 8367 Probes, 543 definition, 381 Prochloraz, 56 Prodrug, definition of, 85 Proenzymes: definition, 427 exotoxins as, 430 Prokaryotes: definition of, 135, 436 osmolality, 755 Proline, 760, 761 Proline isomerases, 849 ProMED-mail, 1099 Promiscuity, definition of, 715 Promoters, 951, 9879 definition, 984 Prophages: definition, 927 in gene mapping, 1010 in SOS response, 933 Propilins, definition of, 454 Propionibacterium spp.

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