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0 g. OrdinaryDifferentialEquations,3rded. Reference solutions. Public-Key Cryptosystem: Authentication [View full size image] In this case, check out Figure 16-15b. 2 Cytokine Receptors and the JAK-STAT Pathway 585 Ile3 Glu2 Glu1 Tyr0 OPO3 SH2 domain (a) JAK2 deactivation induced by SHP1 phosphatase Epo Active JAK2 kinase P EpoR Inactive JAK2 kinase Active SHP1 Inactive SHP1 SH2 domains PP PP Phosphatase domain (b) Signal blocking and protein degradation induced by SOCS proteins PP SOCS PP Recruitment of E3 ubiquitin ligase protein SH2 SOCS domain box PP FIGURE 14-14 Two mechanisms for terminating signal transduction from the erythropoietin receptor (EpoR).

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