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CMML and Ph1 -negative and BCRABL-negative CML appear to overlap clinically in some instances, and their clinical behavior, progress, and response to therapy resemble those of the myelodysplastic syndromes more than Ph1 -positive CML (see Chapter 175). Stuart WestmorlandPhoto Researchers. Histological differentia- tion allows good clinical correlation between a low risk group of patients who are cured and a high risk group who need more intensive treatment and do less well.

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